Genetic diversity and drug resistance profiles of Mycobacterium tuberculosis complex isolates from patients with extrapulmonary tuberculosis in Ghana and their associated host immune responses

•Pleural TB and TB lymphadenitis are the most common forms of extrapulmonary TB in Ghana.•M. tb sub-lineage Cameroon is associated with decreased serum IL-1β, IL-17A, and IFN-α.•A significant association was observed between age and M. tb complex lineages.•Generally, M. bovis contributes minimally to human extrapulmonary TB in Ghana.