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细胞外基质参与调控慢性阻塞性肺疾病气道重塑的研究进展

WANG Chu-wen,HUANG Jia-jia,QIAN Guo-qing

Chinese Journal of Pathophysiology（2022）

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Abstract
慢性阻塞性肺疾病(chronic obstructive pulmo?nary disease,COPD)是一种以气流受限、气道重塑和肺实质破坏为特征的慢性气道炎症性疾病,气道重塑是其发病的关键因素之一.COPD的气道重塑过程主要发生在小气道,随着疾病进展,血管密度增加、黏膜上皮化生增多、黏膜下腺肥大、支气管周围纤维化及气道平滑肌细胞(airway smooth muscle cells,ASMCs)增殖等情况将导致气道壁增厚和气流阻塞[1].人类肺部细胞外基质(extracellular matrix, ECM)变化参与了COPD慢性气道重塑.
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