Comparison of pharmacologic therapies alone versus operative techniques in combination with pharmacologic therapies for postoperative analgesia in patients undergoing laparoscopic cholecystectomy: A randomized controlled trial

•Combined pharmacologic and surgical maneuver analgesia decrease pain following laparoscopic cholecystectomy.•Surgical maneuver analgesia included low pressure pneumoperitoneum, saline irrigation, carbon dioxide aspiration.•These also increased sleep quality in patients following laparoscopic cholecystectomy.•This treatment can be considered instead of treatment with pharmacologic analgesia alone in laparoscopic cholecystectomy.•Combined pharmacologic and surgical maneuver analgesia needs to be tested in a larger, multicenter cohort.