Two Co(Ii) Coordination Polymers: Inhibitory Effect On Chronic Myocarditis By Reducing Expression Levels Of Thehs-Ctntin The Cardiomyocytes

Under the solvothermal conditions, by using the rigid pi-conjugated connector of H4L (5,5 '-[1,3,6,8-tetraoxobenzo [lmn] [3], [8] phenanthroline-2-7-diyl] bis-1,3-benzenedicarboxylic acid) and the nitrogen-donor auxiliary connector, two novel coordination polymers (CPs) based on Co ions as nodes {([Co(L)(0.5)(bpy)(H2O)]center dot 3.5H(2)O)}(n)(1, bpy = 4,4 '-bipyridine) and {[Co(L)(0.5)(1,4-bib)(H2O)(2)]center dot 2 center dot 5H(2)O center dot DMA}(n)(2, 1,4-bib = 1,4-bis[1-imidazoly]benzene) have been synthesized. Furthermore, the treatment activities of the compounds on the pediatric chronic myocarditis were evaluated. The relative expression of thehs-cTnTin the cardiomyocytes was determined by the real-time reverse transcription-polymerase chain reaction (RT-PCR). The inflammatory cytokines content resealed by the cardiomyocytes was also determined using the enzyme linked immunosorbent assay (ELISA) detection kit.