Association of acute increases in serum creatinine with subsequent outcomes in patients with type 2 diabetes mellitus treated with sodium-glucose cotransporter 2 inhibitor or dipeptidyl peptidase-4 inhibitor.
European heart journal. Quality of care & clinical outcomes(2022)
Abstract
A modest increase in serum creatinine (<30%) was common following SGLT2i initiation, and was not associated with worse clinical outcomes, therefore should not stop therapy prematurely, but a larger increase in creatinine following drug therapy was not typical and should raise concern and review of the patient.
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Key words
Dipeptidyl peptidase-4 inhibitor,estimated glomerular filtration rate,sodium glucose cotransporter-2 inhibitor,type 2 diabetes mellitus
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