Immunoinformatics Designing of Multi-Epitope Peptide for Loa Loa Infection Diagnosis

Loiasis is caused by Loa loa, a vector-borne filarial parasitic worm endemic to Central and West Africa. It is a significant public health issue due to its geographic overlap with Onchocerciasis and Lymphatic Filariasis. It has been reported that improper diagnosis of Loiasis can complicate the treatment of Onchocerciasis and Lymphatic Filariasis, causing severe neurological reactions. Due to this, there’s a need for a more sensitive method to detect Loa loa in humans.Hence, the study aimed to predict and design a novel, synthetic multi-epitope protein for diagnosingLoiasis from retrieved Loa loa genes.