Intracellular zinc signaling influences NMDA receptor function by enhancing the interaction of ZnT1 with GluN2A

Rebecca Krall,Jenna R Gale,Madeline M Ross,Thanos Tzounopoulos,Elias Aizenman

SSRN Electronic Journal（2022）

引用 3|浏览4

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摘要

•Increases in intracellular zinc drive metal response element/metal response transcription factor-1 system in neurons.•Increases in intracellular zinc promote the interaction between the zinc transporter ZnT1 and the NMDAR subunit GluN2A.•Increased GluN2A-ZnT1 interactions enhance tonic zinc inhibition of NMDAR currents.

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关键词

Zinc,GluN2A,Metal regulatory element transcription factor 1,ZnT1

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