A comprehensive review on anti-obesity potential of cyperus rotundus in experimental animals

Worldwide, obesity and the illnesses it causes have become serious health issues, and obesity is today the fifth most common cause of death. According to research, there were 641 million obese adults worldwide in 2014. This review was based on detailing of obesity, BMI ranges, anti-obesity potential and signalling pathways of Cyperus rotundus. It covered extensive literature survey from the studies published in PubMed, Elsevier, Google Scholar etc. A member of the Cyperaceae family, Cyperus rotundus grows naturally in tropical and temperate climates and has long been used to heal mental and digestive issues. In order to determine the effectiveness and safety of Cyperus rotundus rhizome extract (CRE), which is standardised to contain Piceatannol, Scirpusin A, and Scirpusin B (5 percent total Stilbenoids), in overweight people, studies have been conducted. Cyperus rotundus has shown dietary enzyme inhibitory action when observed. It significantly lowered the level of all three enzymes i.e., Lipase, Alphaamylase and Alpha- glucosidase. Changes in cell shape and the concentrations of cytoskeletal and extracellular components signal the beginning of adipogenesis. As a result of this process, CCAAT-enhancerbinding proteins (C/EBP) and peroxisome proliferator-activated receptors (PPAR) that are predicated on adipogenicity begin to express themselves. In overweight people, the extract proved successful in lowering body weight and BMI. CRE might prevent obese mice from gaining weight and demonstrated anti-adipogenic effect in differentiated 3T3 L1 adipocytes in-vitro. In conclusion, many current studies have proved for its anti-obesity and lipid lowering potential in various animal or human models. It would be great change towards human use if it is developed into any suitable dosage form for better bioavailability. Keywords: Cyperus rotundus, anti-obesity, anti-hyperlipidaemic, rats, human