Fast imaging-based single particle analysis method for solubility determination

Emma Hokkala,Clare J Strachan,Mikael Agopov,Kristian Semjonov,Jyrki Heinämäki,Jouko Yliruusi,Sami Svanbäck

International Journal of Pharmaceutics（2022）

引用 1|浏览10

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摘要

•Physical technique to measure solubility from micrograms of compound.•No prior knowledge of compound chemistry needed.•Several procedural steps removed compared to traditional solubility-testing methods.•Fast with low material consumption.•Results comparable to those of chemical techniques.

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关键词

Solubility,Dissolution,Single particle,Optical imaging,Image analysis,Miniaturization

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