Towards capturing of totipotency

In June issue of Cell Research,Xu et al.demonstrate that totipotent-like stem cells(TPS cells)can be derived directly from a 2-cell mouse embryo and extended pluripotent stem(EPS)cells by a chemical cocktail(CPEC condition).In addition,the study shows the advanced potential of TPS cells in lineage differentiation and blastocyst-like structure generation,and provides insight into mechanistic regulation of totipotency.