LEVELS OF NATURAL KILLER CELLS IN PATIENTS WITH ANKYLOSING SPONDYLITIS: A META-ANALYSIS

BackgroundAnkylosing Spondylitis(AS) is a complex chronic inflammatory autoimmune disease that mainly affects the spine. Natural Killer (NK) cells are classified among the recently discovered innate lymphoid cell subsets and have capacity to influence both innate and adaptive immune responses. However, the status of NK cells remains debated in AS.ObjectivesThis study aims to clarify the level of peripheral NK cells in AS patient.MethodsWe used CNKI, CBM, Wanfang data and Chinese science, scientific and technological journal data, PubMed, Embase, Web of science, Cochrane library and Medline to collect relevant literature data, and sorted out the proportion of NK cells in AS patients. Random effects were selected to assess pooled data, inconsistency was assessed using I-squared index (I2), and Egger’s test was used to assess potential publication bias (STATA v.12.0).ResultsA total of 11 case-control studies involving 561 AS patients and 592 healthy controls (HC) were included in this study. AS patients had a significantly lower proportion of CD16+CD19+NK cells compared with HCs［SMD=-0.41, 95%CI (-0.71,-0.11), P<0.05,］(Figure 1), with no publication bias according to Egg’s test[t=0.50, P=0.63].ConclusionThe proportion of of CD16+CD19+ NK cells in AS patients was significantly reduced, suggesting disturbance of NK closely involved in the pathogenesis of AS.Table 1.Summary of study characteristics of included records.AuthorPublish yearEIaQbCase numbersNK cell’s definitionData TypeMean % of NK cell(mean(or median)±SD)ASHCQian Liu202147121120CD16+CD56+OriginalAS:17.6HC:138.9Yu Zhang2019463941CD16+CD56+OriginalAS:22.78HC:61.12Wei Hu2019466040CD16+CD56+OriginalAS:13.3HC:48.1Liyuan Zhu2016473030CD16+CD56+OriginalAS:16.23HC:44.58Hua Liu2012456030CD16+CD56+OriginalAS:29.99HC:49.5Yongfang Wang2012466044CD16+CD56+OriginalAS:14.04HC:60.12Yuehu Hua2012473632CD16+CD56+OriginalAS:31.1HC:59.8Li Ma2011464320CD16+CD56+OriginalAS:24.98HC:38.15Xuehua Ma2011463632CD16+CD56+OriginalAS:31.1HC:59.8Yong-Wook Park20094741173CD16+CD56+CalculatedAS:25.4HC:190.4Li Ma2004473530CD16+CD56+OriginalAS:33.48HC:52.37AcknowledgementsThis work was supported by the National Natural Science Foundation of China (No. 82001740).Disclosure of InterestsNone declared