Aryl Ketone-Mediated Light-Driven Naphthylation of C(sp3)–H Bonds Attached to either Oxygen or Nitrogen Substituents
Synthesis(2022)
Abstract
A light-driven naphthylation was achieved at a C(sp3)–H bond attached to either oxygen or nitrogen substituents using sulfonylnaphthalene as a naphthalene precursor in the presence of 4-benzoylpyridine at ambient temperature. The present transformation is proposed to proceed through the generation of a carbon radical species via chemoselective cleavage of the heteroatom-substituted C(sp3)–H bond by photoexcited 4-benzoylpyridine, the addition of the derived carbon radical to the electron-deficient sulfonylnaphthalene, and then rearomatization by releasing sulfinyl radical.
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Key words
C-H functionalization, naphthylation, photoreaction, aryl ketones, ethers, amides
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