HIV-1 Tat induced microglial EVs leads to neuronal synaptodendritic injury: microglia-neuron cross-talk in NeuroHIV.

Muthukumar Kannan,Seema Singh,Divya T. Chemparathy, Abiola A. Oladapo,Dinesh Y. Gawande,Shashank M. Dravid,Shilpa Buch,Susmita Sil

Extracellular vesicles and circulating nucleic acids（2022）

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摘要

In summary, our study underscores the role of microglial NLRP3 as an important contributor to Tat-MDEV mediated synaptodendritic injury. While the role of NLRP3 in inflammation is well-described, its role in EV-mediated neuronal damage is an interesting finding, implicating it as a target for therapeutics in HAND.

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NLRP3,mEPSC,microglia-derived EVs,synaptodendritic injury

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