Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome.

Anna S Kolodziejczak,Lea Guerrini-Rousseau,Julien Masliah Planchon,Jonas Ecker,Florian Selt,Martin Mynarek,Denise Obrecht,Martin Sill,Robert J Autry,Eric Zhao,Steffen Hirsch, Elsa Amouyal,Christelle Dufour,Olivier Ayrault,Jacob Torrejon,Sebastian M Waszak,Vijay Ramaswamy,Virve Pentikainen,Haci Ahmet Demir,Steven C Clifford,Ed C Schwalbe,Luca Massimi,Matija Snuderl,Kristyn Galbraith,Matthias A Karajannis,Katherine Hill,Bryan K Li, Mike Walsh,Christine L White,Shelagh Redmond, Loizou Loizos,Marcus Jakob,Uwe R Kordes,Irene Schmid,Julia Hauer,Claudia Blattmann,Maria Filippidou,Gianluca Piccolo,Wolfram Scheurlen,Ahmed Farrag,Kerstin Grund,Christian Sutter,Torsten Pietsch,Stephan Frank,Denis M Schewe,David Malkin,Myriam Ben-Arush,Astrid Sehested,Tai-Tong Wong,Kuo-Sheng Wu,Yen-Lin Liu,Fernando Carceller,Sabine Mueller,Schuyler Stoller,Michael D Taylor,Uri Tabori,Eric Bouffet,Marcel Kool,Felix Sahm,Andreas von Deimling,Andrey Korshunov,Katja von Hoff,Christian P Kratz,Dominik Sturm,David T W Jones,Stefan Rutkowski,Cornelis M van Tilburg,Olaf Witt,Gaëlle Bougeard,Kristian W Pajtler,Stefan M Pfister,Franck Bourdeaut,Till Milde

Neuro-Oncology（2023）

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摘要

LFS MB patients have a dismal prognosis. In the presented cohort use of RT significantly increased survival rates, whereas chemotherapy intensity did not influence their clinical outcome. Prospective collection of clinical data and development of novel treatments are required to improve the outcome of LFS MB patients.

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关键词

Li-Fraumeni syndrome, medulloblastoma, survival, TP53

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