Quercetin-Loaded Nanocomposite Microspheres for Chronologically Promoting Bone Repair Via Synergistic Immunoregulation and Osteogenesis

•Quercetin-loaded microspheres with “eyeball-like” morphology were prepared by airflow shearing method.•The encapsulation efficiency of quercetin-loaded microspheres reached nearly 80%, and possessed sustained release behavior.•The quercetin-loaded microspheres promoted osteogenesis via modulating macrophage M2 polarization in the co-culture system.•The quercetin-loaded microspheres displayed excellent immunoregulation and bone repair in vivo.