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JDQ443, a Covalent Inhibitor of KRASG12C with a Novel Binding Mode, Shows Broad Antitumor Activity in KRASG12C Preclinical Models As a Single Agent and in Combination with Inhibitors of SHP2, MEK or CDK4/6

Andreas Weiss,Hans Voshol,Diana Graus Porta,Carmine Fedele,Dario Sterker,Ruben De Kanter,Rowan Stringer,Toni Widmer,Alice Loo,Daniel A. Guthy,Kim S. Beyer,Nils Ostermann,Catherine LeBlanc,Marc Gerspacher,Andrea Vaupel,Richard Sedrani,Frederic Zecri,Saveur-Michel Maria,Francesco Hofmann,Peter Hammerman,Jeff Engelman,Edwige Lorthiois,Simona Cotesta,Saskia M. Brachmann

CANCER RESEARCH（2022）

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