Design, synthesis, and structural activity relationship of antimicrobial peptides against multi-drug resistant organisms

Antimicrobial peptides (AMPs) are a family of tiny peptides found throughout nature that play a vital role in various organisms' innate immune systems. Antimicrobial peptides and proteins (AMPs) are a varied family of naturally occurring chemicals produced by all multicellular organisms as a first line of defense. The rising prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) diseases is the most evident cause for concern. Traditional antimicrobial drugs work by targeting certain metabolic pathways or microbiological structures to kill or hinder bacterial growth. The development of new lead structures to combat multidrug-resistant bacteria is critical, and cationic antimicrobial peptides (AMPs) have the ability to do so. Based on the SPOT synthesis, we present an outline of a strategy for screening peptides for antimicrobial activity. Multidrug-resistant bacteria have grown fast in recent decades, leading to a rise in nosocomial infections and in-hospital mortality, as well as posing a threat to world health. We can say that he discovery of antibiotics signaled the start of a golden period in human medicine.