Activation of immune receptor RIG-I protects human differentiated epithelial cells of the upper respiratory tract from SARS-CoV-2

Evelyn Hartmann,Beate Kümmerer,Lara Oberkircher,Natalio Garbi,Sebastian Strieth,Gunther Hartmann

Abstract- und Posterband - 93. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn Interface - Fokus Mensch im Zeitalter der technisierten MedizinLaryngo-Rhino-Otologie（2022）

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摘要

SARS-CoV-2 virus has evolved non structural proteins (NSLs) to avoid recogniton by innate immune receptors such as RIG-I which induces an antiviral type I IFN response. A proper type I IFN response is essential for an effective defense against SARS-CoV-2. The aim of this project is the evaluation of the effect of a prophylactic activation of RIG-I by a specific synthetic RNA ligand (5´-triphosphate RNA, 3pRNA) to an antiviral state in cells that protects against SARS-CoV-2.

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关键词

epithelial cells,upper respiratory tract,receptor,sars-cov

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