MiR-1306-5p promotes cell proliferation and inhibits cell apoptosis in acute myeloid leukemia by downregulating PHF6 expression

Leukemia Research（2022）

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摘要

•miR-1306–3p plays an oncogene role in AML patients.•miR-1306–5p facilitates proliferation and reduces apoptosis.•miR-1306–3p promotes AML via directly targeting PHF6.•This research provides a rationale for a novel m-RNA based therapy to increase response in AML.

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关键词

Acute myeloid leukemia,MicroRNA-1306–5p,PHD finger protein 6,Proliferation,Apoptosis

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