A high-throughput viral integration sequencing method reveals that mitochondrial DNA is frequently targeted by HBV integration

Domenico Giosa,Daniele Lombardo,Cristina Musolino,Valeria Chines,Giuseppina Raffa,Deborah D'aliberti,Francesca Casuscelli di Tocco,Carlo Saitta,Riccardo Aiese Cigliano,Orazio Romeo,Angela Alibrandi,Giuseppe Navarra,Giovanni Raimondo,Teresa Pollicino

JOURNAL OF HEPATOLOGY（2022）

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摘要

Figure 1: Bland-Altmann plot of Xpert HBV minus Abbott qPCR (vertical axis) against mean of Xpert HBV and Abbott qPCR (horizontal axis) for samples with detectable viral load (n = 110). Conclusion:The Xpert HBV DNA test provides a reliable alternative for detecting and quantifying HBV DNAviral load using stored plasma samples.However, the assay is not reliable for detecting viremia from DBS samples.

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关键词

hbv integration,viral integration,mitochondrial dna,high-throughput

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