A Flexible and Original Architecture of Two Unrelated Zinc Fingers Underlies the Role of the Multitask P1 in RYMV Spread

Vianney Poignavent,François Hoh,Guillaume Terral,Yinshan Yang,François-Xavier Gillet,Jeong-Hyeon Kim,Frédéric Allemand,Eric Lacombe,Christophe Brugidou,Sarah Cianferani,Hélène Déméné,Florence Vignols

Journal of Molecular Biology（2022）

引用 4|浏览22

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摘要

•Phytoviral RNA silencing suppressors remain poorly analyzed at the structural level.•We report the first semi-flexible 3D structure of a sobemoviral RNAi suppressor (P1)•A CCCC-type ZnF1 ensures the folding of P1 Nter region required for viral infectivity.•A second extremely rare HCHC-type ZnF2 at P1 Cter region behaves as a redox sensor.•Multiple levels of P1 structural regulation support P1 key functions in viral spread.

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关键词

3D structure,Oryza sativa,Sobemovirus,viral movement protein,zinc finger protein

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