Stress-induced cardiometabolic perturbations, increased oxidative stress and ACE/ACE2 imbalance are improved by endurance training in rats

Vinicius Guzzoni,Andrea Sanches,Rafaela Costa,Lívia Bruni de Souza,Lília Taddeo Firoozmand,Isabel Cristina Mallosto Emerich de Abreu,Joyce Ferreira da Costa Guerra,Maria Lúcia Pedrosa,Dulce Elena Casarini,Fernanda Klein Marcondes,Tatiana Sousa Cunha

Life Sciences（2022）

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摘要

•Chronic stress impaired glucose tolerance and insulin sensitivity in rats.•Endurance training attenuated the stress-related dyslipidemia.•Endurance training mitigated the elevated circulating adrenaline induced by stress.•Endurance training improved the antioxidant capacity of stressed rats.•High-volume endurance training improved the balance of ACE/ACE2 activity.

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关键词

Chronic stress,Endurance training,Metabolism,Angiotensin-converting enzymes,Heart

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