Two cases of white globe appearance in the stomach after vonoprazan administration

White globe appearance (WGA) has been recently reported as a novel endoscopic marker that can help differentiate between gastric cancer and low-grade adenoma. Here, we describe two cases of WGAs after vonoprazan administration. Case 1 was of a woman in her seventies who had been diagnosed with gastroesophageal reflux disease (GERD) and treated with vonoprazan for 11 months. Esophagogastroduodenoscopy revealed WGAs in the fornix and body of the stomach. The WGA was located underneath the epithelium with overlying microvessels. Histopathology revealed eosinophilic material with necrotic fragments in the dilated glands. Case 2 was of a woman in her eighties who had been diagnosed with GERD and treated with vonoprazan for 1.3 year. Esophagogastroduodenoscopy revealed WGAs in the fornix and body of the stomach. The WGA located underneath the epithelium with overlying microvessels. Histopathology revealed eosinophilic material with necrotic fragments in the dilated glands and parietal cell protrusion.