VEGF and VEGFR family members are expressed by neoplastic cells of NF1-associated tumors and may play an oncogenic role in malignant peripheral nerve sheath tumor growth through an autocrine loop

Benjamin Bonsang, Laurent Maksimovic,Pascale Maille,Nadine Martin,Ingrid Laurendeau,Eric Pasmant,Ivan Bièche, Justin Deschamps,Pierre Wolkenstein,Nicolas Ortonne

Annals of Diagnostic Pathology（2022）

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摘要

Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder. The role of angiogenesis and VEGF pathway in the pathogenesis of neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) remains poorly understood.

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关键词

VEGF,VEGF-R,Neurofibromatosis type 1,Neurofibroma,Malignant peripheral nerve sheath tumor

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