Stress level of glucocorticoid exacerbates neuronal damage and Aβ production through activating NLRP1 inflammasome in primary cultured hippocampal neurons of APP-PS1 mice

•The hippocampal neurons of APP/PS1 mice are more sensitive to glucocorticoid than WT mice.•Chronic glucocorticoid accelerates neuronal damage and Aβ production in neurons of APP/PS1 mice.•Chronic glucocorticoid increases the expressions of NOX2 and NLRP1 in neurons of APP/PS1 mice.•NLRP1-siRNA alleviates the neuronal damage and Aβ production in glucocorticoid-induced APP/PS1 mice.