Proton Pump Inhibitor Use and Obesity-Associated Cancers in the Women's Health Initiative
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION(2022)
Abstract
Among postmenopausal women, PPI use, but not H2RA use, demonstrated an inverse, dose-responsive association with colorectal cancer incidence. This was consistent with preclinical data that FAS inhibition prevents colon cancer progression and supports further investigation of this commonly used medication as a cancer preventive agent. PPI use was not associated with incidence of breast or endometrial cancer.
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Key words
proton,inhibitor,obesity-associated
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