Transplantation of human cells into Interleukin-2 receptor gamma gene knockout pigs under several conditions

Koki Hasegawa,Kazuaki Nakano,Masaki Nagaya,Masahito Watanabe,Ayuko Uchikura,Hitomi Matsunari,Kazuhiro Umeyama,Eiji Kobayashi,Hiroshi Nagashima

Regenerative Therapy（2022）

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摘要

•The present study aimed to evaluate whether IL2RG KO SCID-like pigs can host and support the growth of xenografted human cells under several conditions.•Tumors from transplanted cells quickly developed in all pigs, as verified by histology and immunohistochemistry.•IL2RG KO pigs have the potential to become extremely useful animal models in a variety of translational biology fields.

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关键词

Interleukin-2 receptor gamma,SCID,Pig,Xenotransplantation

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