Combining Donor-derived Cell-free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses and Histology as Confirmation.

Philip F Halloran,Jeff Reeve,Katelynn S Madill-Thomsen,Navchetan Kaur,Ebad Ahmed, Carlos Cantos,Nour Al Haj Baddar,Zachary Demko,Nathan Liang,Ryan K Swenerton,Bernhard G Zimmermann,Paul Van Hummelen,Adam Prewett,Matthew Rabinowitz,Hossein Tabriziani, Phil Gauthier,Paul Billings

Transplantation（2022）

引用 11|浏览30

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摘要

This prospective, biopsy-matched, multisite dd-cfDNA study in kidney transplant patients found that the combination of dd-cfDNA fraction and quantity was more powerful than either dd-cfDNA fraction or quantity alone and validated a novel two-threshold algorithm incorporating both variables.

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关键词

kidney transplant rejection,dna,donor-derived,cell-free

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