Determination of RNA-ligand interactions with the photoaffinity platform PEARL-seq
Methods（2022）
Abstract
•RNA-ligand interactions are of increasing therapeutic interest.•RNA-targeted small molecules can be developed into photoprobes.•PEARL-seq enables nucleotide-level determination of ligand-RNA interaction.•Enrichment analysis shows transcriptome-wide binding preferences.
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Key words
RNA therapeutics,RNA structure,Target engagement,Chemical biology
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