Effects of treatment with clinically relevant valproate, carbamazepine, oxcarbazepine, topiramate, lamotrigine and levetiracetam on ovarian folliculogenesis in young rats

Ali Cansu,Seren Gulsen Gurgen, Yeseren Nil Demirhan,Pınar Ozkan Kart,Mehmet Yildirim,Ahmet Alver,Engin Yeni̇lmez,Fatma Müjgan Sönmez

Epilepsy Research（2022）

引用 4|浏览13

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摘要

•ASMs affect female reproductive functions.•ASMs caused a decrease in the number of follicles, an increase in the number of corpus luteum and apoptosis.•ASMs cause a decrease in the concentration of growth factors that affect ovarian development.•Exposure to VPA, CBZ, OXC, TPM, LTG and LEV caused different levels of impaired folliculogenesis in young rats.

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关键词

Anti-seizures medications,Apoptosis,Caspase-3,GDF-9,Ovary

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