Gene expression-based prediction of pazopanib efficacy in sarcoma

Christoph E. Heilig, Andreas Laßmann,Sadaf S. Mughal,Andreas Mock, Sebastian Pirmann,Veronica Teleanu,Marcus Renner,Carolin Andresen,Bruno C. Köhler,Bogac Aybey,Sebastian Bauer,Jens T. Siveke,Rainer Hamacher,Gunnar Folprecht,Stephan Richter,Evelin Schröck,Christian H. Brandts,Marit Ahrens,Peter Hohenberger,Gerlinde Egerer

European Journal of Cancer（2022）

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摘要

•Reliable predictors of pazopanib efficacy in soft-tissue sarcoma are lacking.•A gene expression-based score stratifies patients with sarcoma regarding pazopanib benefit.•The score is not predictive in patients with sarcoma who received other therapies.•The pazopanib efficacy predictor warrants prospective clinical investigation.

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关键词

Sarcoma,Precision oncology,Multi-omics,Predictor,Pazopanib

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