LncRNA LOC105378097 inhibits cardiac mitophagy in natural ageing mice.

Xin Liu,Xue Bai,Heng Liu,Yang Hong,Hao Cui,Lei Wang,Wanqing Xu,Limin Zhao,Xiaohan Li,Huimin Li,Xia Li,Hui Chen,Ziyu Meng,Han Lou,Henghui Xu,Yuan Lin,Zhimin Du,Philipp Kopylov,Baofeng Yang,Yong Zhang

Clinical and translational medicine（2022）

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摘要

The present study for the first time demonstrates a heart-enriched lncRNA, SMAL, that inhibits the mitophagy of cardiomyocytes via the downregulation of Parkin protein, which further contributes to heart ageing and cardiac dysfunction in natural ageing mice.

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关键词

LOC105378097,Parkin,cardiac function,heart ageing,mitophagy

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