Toll-like receptor-mediated neuroinflammation: relevance for cognitive dysfunctions

Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) with a well -documented role in the innate and adaptive immune responses. Interestingly, TLR activation has also been linked to several brain functions including neurogenesis and synaptogenesis. Increasing evidence supports TLR involvement in peripheral and central inflammation underlying normal aging and the pathogenesis of clinical conditions characterized by cognitive decline. These include not only major neuro-degenerative diseases but also traumatic brain injuries, surgeries, and alcohol consumption-and chemotherapy-induced cognitive impairment. We first summa-rize the physiological roles of TLRs in the nervous system, and then illustrate the emerging involvement of TLRs in cognitive functions, pointing to these receptors as novel enticing pharmacological targets to develop more efficient drugs for the treatment of cognitive impairment.