False positive anti-Topoisomerase I (Scl-70) antibody results in clinical practice: A case series from a scleroderma referral center

Brian H Lam,Shervin Assassi,Julio Charles,Rana Taherian,Marka A Lyons,Bochra Jandali,Maureen D Mayes,Brian Skaug

Seminars in Arthritis and Rheumatism（2022）

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摘要

•48 patients with a positive Scl-70 antibody result were negative by immunodiffusion.•Most patients had no specific clinical manifestations of systemic sclerosis.•37.5% of patients tested negative for ANA by indirect immunofluorescence.

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关键词

Systemic sclerosis,Scleroderma,Scl-70 antibody,Topoisomerase I antibody,ANA,Immunodiffusion

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