Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit
Journal of perinatology : official journal of the California Perinatal Association(2022)
摘要
Objective To identify the relationship between prophylactic indomethacin (PI) administration and incidence of intraventricular hemorrhage. Study design A retrospective analysis of extremely premature infants <27 weeks gestational age born between January 2014 and September 2020. Results A total of 421 infants were included from three of Nationwide Children’s Hospital delivery centers. Of those 255 (61%) received PI. After adjustment by inverse proportionality treatment weighting (IPTW), no differences were found in incidence of intraventricular hemorrhage (IVH) at the time of the first ultrasound, 31% vs. 33% in PI and control groups respectively ( p = 0.68). The rate of rise of serum creatinine from baseline to day of life four was significantly higher in the PI group (0.14 mg/dl PI and 0.03 mg/dl control, p < 0.001). Conclusion PI was not associated with any benefit in prevention of IVH, but is associated with adverse effects including acute rise in creatinine.
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关键词
Brain injuries,Outcomes research,Prognostic markers,Respiratory signs and symptoms,Medicine/Public Health,general,Pediatrics,Pediatric Surgery
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