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Hcy及MTHFR C677T多态与牡丹江汉族高血压相关性研究

DAI Haibing,SHI Jiayi,WANG Han,LIU Xia,SONG Jie

Laboratory Science（2022）

Cited 0|Views8
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Abstract
探讨了同型半胱氨酸(Hcy)及5,10-亚甲基四氢叶酸还原酶(MTHFR)C677T基因多态性与牡丹江地区汉族原发性高血压(essential hypertension,EH)的相关性.采用PCR-RLFP的方法检测牡丹江地区汉族208例MTHFR C677T基因型,同时检测血浆Hcy水平.结果显示血浆Hcy水平与原发性高血压和正常对照组差异有统计学意义(OR=1.06795％CI 1.003～1.135,P<0.05).基因多态与汉族原发性高血压不具有相关性(P>0.05),汉族MTHFR C677T TT基因型Hcy水平高于其他两基因型人群,差异具有统计学意义(P<0.05).结果表明Hcy水平与原发性高血压的具有正相关性,MTHFR C677T基因多态性与原发性高血压的发生不相关,但TT基因型与Hcy水平正相关.
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