Frequent Low-Dose Δ9-Tetrahydrocannabinol in Adolescence Disrupts Microglia Homeostasis and Disables Responses to Microbial Infection and Social Stress in Young Adulthood

Hye-Lim Lee,Kwang-Mook Jung,Yannick Fotio,Erica Squire,Francesca Palese,Lin Lin,Alexa Torrens,Faizy Ahmed,Alex Mabou Tagne,Jade Ramirez,Shiqi Su,Christina Renee Wong, Daniel Hojin Jung,Vanessa M. Scarfone,Pauline U. Nguyen,Marcelo Wood,Kim Green,Daniele Piomelli

Biological psychiatry（2022）

引用 13|浏览13

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摘要

Daily low-intensity CB receptor activation by THC during adolescence may disable critical functions served by microglia until young adulthood with potentially wide-ranging consequences for brain and mental health.

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关键词

Adolescence,Endocannabinoid,Immune response,Microglia,Social stress,Δ(9)-tetrahydrocannabinol

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