The Prognostic Significance of the BIN1 and CCND2 Gene in Adult Patients with Acute Myeloid Leukemia

Objective To investigate the expression and clinical significance of Bridging INtegrator 1 ( BIN1 ) and cyclin D2 ( CCND2 ) in newly diagnosed cytogenetically heterogenous adult acute myeloid leukemia patients. Methods Real-time quantitative PCR (RQ-PCR) was used to detect the expression of BIN1 and CCND2 genes in 49 newly diagnosed adult patients with AML, and their clinical significance was analyzed. Results BIN1 and CCND2 genes are highly expressed in patients with AML, which suggest their potential as molecular markers. A statistical significant correlation was found between BIN1 expression with bone marrow blasts ( P = 0.012), CD34 expression ( P = 0.026), NLR ( P = 0.019) and Karyotype risk ( P = 0.005). There was a statistically significant correlation between CCND2 and age ( P = 0.001), NLR ( P = 0.046) Karyotype risk ( P = 0.033). The expression level of BIN1 was related to early treatment response (CR or not) ( P = 0.043). CCND2 expression was significantly correlated with overall survival ( P = 0.013), but not with CR ( P = 0.731). Conclusion BIN1 and CCND2 genes are highly expressed in patients with AML, suggesting the potential of these two genes as molecular markers. Moreover, high levels of CCND2 are associated with better prognosis, suggesting the possibility of these two genes as prognostic markers.