Immunosuppressive treatments selectively affect the humoral and cellular response to SARS-CoV-2 in vaccinated patients with vasculitis.

Sara Monti, Chiara Fornara,Paolo Delvino,Alice Bartoletti,Federica Bergami,Giuditta Comolli,Josè Camilla Sammartino,Alessandro Biglia,Emanuele Bozzalla Cassione,Irene Cassaniti,Fausto Baldanti,Daniele Lilleri,Carlomaurizio Montecucco

Rheumatology (Oxford, England)（2023）

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摘要

Although patients with GCA apparently achieve a robust antibody seroconversion, there is a significant impairment of the neutralizing activity. MTX significantly reduced all levels of the humoral response. Up to one-third of patients do not develop a cellular immune protection in response to COVID-19 vaccination.

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关键词

COVID-19,GCA,cellular response,immune response,vaccination,vasculitis

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