Structural Analysis and Development of Notum Fragment Screening Hits
Yuguang Zhao,William Mahy,Nicky J. Willis,Hannah L. Woodward,David Steadman,Elliott D. Bayle,Benjamin N. Atkinson,James Sipthorp,Luca Vecchia,Reinis R. Ruza,Karl Harlos,Fiona Jeganathan, Stefan Constantinou,Artur Costa,Svend Kjaer,Magda Bictash,Patricia C. Salinas,Paul Whiting,Jean-Paul Vincent,Paul Fish,E. Yvonne Jones ACS CHEMICAL NEUROSCIENCE（2022）
关键词
Notum inhibitors,fragment screening,Diamond-SGC Poised Library (DSPL),hit-to-lead development,Wnt signaling
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