Activation and Speciation Mechanisms in Class A GPCRs
Journal of Molecular Biology(2022)
摘要
Distribution of Class A GPCRs in the reduced conformational space spanned by two principal components determined by PCA of a large ensemble of structures. Each point represents a GPCR. The GPCRs are clustered by species to which they belong and by the activation state of the receptor. Two ribbon diagrams illustrate the major structural differences between conformers lying in different regions of the conformational space.
更多查看译文
关键词
G-protein coupled receptors,signature dynamics,conformational landscape,principal component analysis,elastic network model
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要