Activation and Speciation Mechanisms in Class A GPCRs

Distribution of Class A GPCRs in the reduced conformational space spanned by two principal components determined by PCA of a large ensemble of structures. Each point represents a GPCR. The GPCRs are clustered by species to which they belong and by the activation state of the receptor. Two ribbon diagrams illustrate the major structural differences between conformers lying in different regions of the conformational space.