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ACT001 suppressing M1 polarization against inflammation via NF-κB and STAT1 signaling pathways alleviates acute lung injury in mice

Hui Guo,Yan Song,Fanjian Li,Yan Fan,Yiman Li,Chaonan Zhang,Huijie Hou, Minmin Shi,Zilong Zhao,Zhe Chen

International Immunopharmacology（2022）

Cited 9|Views3
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Abstract
•ACT001 conferred potent protection against LPS-induced acute lung injury in mice.•ACT001 inhibited M1 macrophage polarization, limiting its pro-inflammatory activity.•ACT001 suppressed NF-κB and STAT1 signaling by targeting IKKβ as well as STAT1.
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Key words
ACT001,Acute lung injury,Macrophage polarization,NF-κB,STAT1
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