An integrated micro-extracting system facilitates lesion-free biomacromolecules enrichment and detection

Xiaoyi Mo,Zhenxing Wen,Shengli Zhao,Jingshan Mo,Fanmao Liu,Meiwan Chen,Changyuan Zhan, Meng Zhang,Ji Wang,Shifeng Wen,Xi Xie,Hui-Jiuan Chen,Bailing Chen

Materials & Design（2022）

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摘要

•The micro-extracting system effectively extracts subcutaneous interstitial fluid in a minimally invasive manner.•The negative pressure can enrich biomacromolecules and improve their concentration correlation with blood.•The micro-extracting system enables the broad use of MN-based microdevices for biomarkers capture and analysis.

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关键词

Microchannels,Microneedle,Negative pressure,Biomacromolecular markers,Detection

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