Collagen scaffold loaded allogeneic neural stem cells promoted locomotion recovery of spinal cord injury mainly through secreting neurotrophic factors

Shuo Liu,Caixia Fan,Yuanyuan Xie,Liudi Wang,Yanyan Cui,Bin Wang

Materials & Design（2022）

Cited 0|Views14

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Abstract

•A oriented collagen fiber scaffold loading NSCs for treating SCI.•Grafted different forms of NSCs restored the motor function to similar levels.•Different forms of NSCs secreted neurotrophic factors led to similar SCI recovery.

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Key words

Spinal cord injury,Neural stem cells,Neurotrophic factors,Collagen scaffold,Paracrine,Locomotion recovery

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