EGFR promotes the apoptosis of CD4 + T lymphocytes through TBK1/Glut1 induced Warburg effect in sepsis.

Li Huang,Xuedi Zhang,Junyu Fan,Xiaolei Liu,Shuhua Luo,Dianqing Cao,Youtan Liu,Zhengyuan Xia,Hanhui Zhong,Cuiping Chen,Liangqing Zhang,Zhifeng Liu,Jing Tang

Journal of advanced research（2023）

引用 7|浏览10

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摘要

Our data demonstrated that through its downstream TBK1/Exo84/RalA protein system, EGFR regulates Glut1 transporting to the cell surface, which is a key step for inducing the Warburg effect and the subsequent cellular activation and apoptosis of CD4 T lymphocytes and may eventually affect the immune functional status, causing immune cell exhaustion in sepsis.

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关键词

Activation,Apoptosis,CD4(+) T lymphocytes,EGFR,Glycolysis,Sepsis

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