2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains.

Sambashiva Banala,Ariana N Tkachuk,Ronak Patel,Pratik Kumar,Timothy A Brown,Luke D Lavis

ACS bio & med chem Au（2022）

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摘要

Small-molecule fluorescent stains enable the imaging of cellular structures without the need for genetic manipulation. Here, we introduce 2,7-diaminobenzopyrylium (DAB) dyes as live-cell mitochondrial stains excited with violet light. This amalgam of the coumarin and rhodamine fluorophore structures yields dyes with high photostability and tunable spectral properties.

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