Prognostic Significance of YAP1 Expression and its Association with Neuroendocrine Markers in Resected Pulmonary Large Cell Neuroendocrine Carcinoma (Lcnec)

•It is the first study to determine the prognostic relevance of YAP1 in pulmonary LCNEC. And we found YAP1 is a prognostic factor for worse survival, especially for DFS.•We investigated the relationship between YAP1 and NE markers (INSM1, DLL3, NeuroD1) and found that YAP1 expression was negatively correlated with INSM1 and DLL3, but not significantly correlated with NeuroD1.•Our sample size is large and the clinical data is complete.•The exploration of the prognostic mechanism of LCNEC is of great significance to its subtype classification and stratification of treatment and prognosis.