Cumulative Mtb infection incidence (measured primarily by TST) among infants with HIV exposure: observational follow-up of an isoniazid prophylaxis trial

Sylvia M LaCourse,Jaclyn N. Escudero,Jerphason Mecha,AJ Warr,Barbra A. Richardson,Naziat Carimo,Lisa M. Cranmer,Elizabeth Maleche-Obimbo,Daniel Matemo,John Kinuthia,Thomas R. Hawn,Grace John-Stewart

Clinical Infectious Diseases（2022）

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摘要

Abstract Cumulative 24-month M. tuberculosis infection incidence (measured primarily by TST) was high among HIV-exposed uninfected infants (8.7/100 person-years [95%CI 6.3-11.9)]. Trend for decreased TST-positivity among infants randomized to isoniazid at 6 weeks of age at trial end (12 months post-enrollment) was not sustained through observational follow-up to 24-months of age.

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关键词

tuberculin skin test,human immunodeficiency virus exposure,tuberculosis</i>,infection incidence,human immunodeficiency virus

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