Human Herpesvirus-6 Detection in Cerebrospinal Fluid on the BioFire FilmArray Meningitis/Encephalitis Panel in a High Human Immunodeficiency Virus-Prevalence African Setting

James Milburn,Kwana Lechiile,Keatlaretse Siamisang,Christopher G Williams,Leah Owen,Ezekiel Gwakuba,Tichaona Machiya,Tshepo Leeme, Hannah E Barton,Ronan Doyle,Mark W Tenforde,Madisa Mine,David M Goldfarb,Margaret Mokomane,Joseph N Jarvis

Open Forum Infectious Diseases（2022）

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摘要

The prevalence and clinical relevance of human herpesvirus-6 (HHV-6) detection in cerebrospinal fluid (CSF) using multiplex polymerase chain reaction (PCR) testing in patients with suspected meningoencephalitis in high human immunodeficiency virus-prevalence African settings are not known. We describe the clinical and laboratory characteristics of 13 patients with HHV-6 CSF PCR positivity in Botswana.

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cerebrospinal fluid, encephalitis, HIV, human herpesvirus-6, meningitis

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