Structural variation between neuropeptide isoforms affects function in the lobster cardiac system

Audrey J. Muscato,Daniel J. Powell,Warsameh Bulhan, Evalyn S. Mackenzie,Alixander Pupo,Madeline Rolph,Andrew E. Christie,Patsy S. Dickinson

General and Comparative Endocrinology（2022）

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摘要

•AST-C isoforms elicit both similar and different responses in the lobster heart.•C-terminal amidation does not account for the different responses to AST-C isoforms.•Single amino acids changes in AST-C conserved sequence explain response differences.

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关键词

Neuropeptide,Isoforms,Crustacea,Structure–function,Allatostatin,Heartbeat

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